Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 23 0.0 0.724 0.129 0.226
biological_process el 23 0.061 0.954 0.626 0.275
biological_process ka 23 0.0 0.684 0.128 0.224
biological_process rf 23 0.0 0.724 0.129 0.226
cellular_component ct 24 0.0 0.878 0.161 0.233
cellular_component el 24 0.011 0.955 0.503 0.287
cellular_component ka 24 0.0 0.884 0.167 0.237
cellular_component rf 24 0.0 0.871 0.161 0.232
disease ct 15 0.001 0.694 0.06 0.17
disease el 15 0.005 0.562 0.084 0.137
disease ka 15 0.0 0.721 0.06 0.177
disease rf 15 0.001 0.692 0.06 0.17
interaction ct 26 0.0 0.668 0.032 0.128
interaction el 26 0.0 0.715 0.032 0.137
interaction ka 26 0.0 0.919 0.157 0.264
interaction rf 26 0.0 0.659 0.031 0.126
molecular_function ct 24 0.0 0.994 0.277 0.335
molecular_function el 24 0.085 0.955 0.487 0.286
molecular_function ka 24 0.0 0.97 0.272 0.334
molecular_function rf 24 0.0 0.994 0.275 0.336
phenotype ct 16 0.0 0.89 0.142 0.243
phenotype el 16 0.167 0.86 0.5 0.203
phenotype ka 16 0.0 0.955 0.145 0.253
phenotype rf 16 0.0 0.876 0.141 0.24

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 26 0.0 0.893 0.17 0.298
integration_mean_by_presence el 26 0.0 0.872 0.241 0.268
integration_mean_by_presence ka 26 0.0 0.273 0.028 0.061
integration_mean_by_presence rf 26 0.0 0.052 0.006 0.011
mean ct 26 0.0 0.884 0.145 0.28
mean el 26 0.0 0.818 0.138 0.212
mean ka 26 0.0 0.186 0.011 0.036
mean rf 26 0.0 0.211 0.013 0.041

CDF plots of non integrated kernels

CDF plots of integrated kernels